There isn't an established "best dose" for 7-hydroxymitragynine. Due to its potency, small amounts can have powerful effects. Most people consuming kratom products are already taking small doses of 7-hydroxymitragynine, which naturally occurs in very low concentrations in kratom leaves.
Dosage can vary depending on a person's body weight, tolerance, and sensitivity to these types of products. It can also vary depending on the product the person is taking.
In general, it’s best to:
Start low: Begin with a small dose of kratom, as the 7-hydroxymitragynine content is part of the overall alkaloid profile.
Increase slowly: Gradually increase the dose if needed, but do so cautiously.